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They say a dog is a man’s best friend, but what if the man is a total dirtbag? In that case, it might be time for some sweet revenge, doggy style. When Reggie (Will Ferrell), a naïve, relentlessly optimistic Border Terrier, is abandoned on the mean city streets by his lowlife owner, Doug (Will Forte; The Last Man on Earth, Nebraska), Reggie is certain that his beloved owner would never leave him on purpose.